The advantage of vibrotherapy over other rehabilitation methods is manifested in its comprehensive effect. In one go, we get an increase in microcirculation, a reduction in swelling, a decrease in pain and a decrease in stiffness. Vibrotherapy accelerates the healing process by stimulating angiogenesis, increasing levels of monocyte chemotactic protein MCP-1, vascular endothelial growth factor VEGF and insulin-like growth factor IGF-1 in the wound. Two different signal frequencies of 30 Hz and 100 Hz, combined with two amounts of acceleration, 0.15 g or 1 g, significantly increases the number of macrophages after 3 days of stimulation. The benefits of vibrotherapy in tissue regeneration have been proven to be based not only on reducing inflammation, but also on stimulating pro-healing macrophages, which are responsible for phagocytosis, proliferation, angiogenesis and collagen spreading. Vibrotherapy applied 3 times a day for 30 minutes resulted in up to 62% of patients getting rid of ulcers in just 7 weeks. Vibrotherapy treatments resulted in a reduction in pain in 94% and a significant reduction in effusion in 52% of patients. Whole-body vibration can increase transcutaneous oxygen levels with useful implications in preventing or treating complications associated with reduced blood perfusion in diabetic foot syndrome.